This subject aims to impart the principles of population based (epidemiologic) evidence to the understanding of variations in the outcome of illness and the reasons thereof (Clinical Epidemiology) thereby providing the framework for finding the best answers to "real world" questions about clinical practice and health care. Individuals taking this course (who usually have a health care background) acquire the basic skills required to understand the fundamental questions about the effectiveness of clinical therapies, usefulness of screening and diagnostic tools, prognosis and disease causation and gain the skills required of effective Evidence-Based Medicine practitioners.